aripiprazole

Image of Aripiprazole used in the treatment of Schizophrenia, Manic Episode Bipolar Disorder, Major Clinical Depression, Autism
ARIPIPRAZOLE ABILIFY ARIPIPREX
Bristol-Myers Squibb
Brand Name in IndiaPharmaceutical Company
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ARIZE East West

What Is Aripiprazole?

Aripiprazole is a partial dopamine agonist of the second generation class of atypical antipsychotics with additional antidepressant properties.

Brand Names Aripiprazole

Abilify, Aripiprex

Developer Manufacturer FDA Approval

Aripiprazole was developed by Otsuka in Japan, and in the United States, Otsuka America markets it jointly with Bristol-Myers Squibb.

Therapeutic Uses Aripiprazole

  • 1 Bipolar disorder
  • 2 Major depression
  • 3 Autism
  • 4 Cocaine dependency
  • 5 Methamphetamine dependency

Dosage Aripiprazole

  • Tablet: 2 mg, 5 mg, 10 mg, 15 mg, 20 mg, 30 mg
  • Tablet: (soluble in mouth)orally10 mg 15mg-vanilla flavor
  • Liquid: oral: 1 mg/mL (150 mL) -orange cream flavor
  • Injection: Intramuscular 9.75 mg/mL (1.3 mL)

Common side effects in adults Aripiprazole

  • nausea
  • vomiting
  • constipation
  • headache
  • dizziness
  • inner sense of restlessness/need to move (akathisia)
  • anxiety
  • insomnia
  • restlessness

Common side effects in children -Aripiprazole


  • feeling sleepy
  • headache
  • vomiting
  • fatigue
  • increased appetite
  • insomnia
  • nausea
  • stuffy nose
  • weight gain
  • uncontrolled movement such as restlessness, tremor muscle stiffness

    • Infrequent side effects Aripiprazole

    • Uncontrollable twitching or jerking movements, tremors, seizure, and weight gain.
    • Some people may feel dizzy, especially when getting up from a lying or sitting position, or may experience a fast heart rate.
    • Neuroleptic malignant syndrome (Combination of fever, muscle stiffness, faster breathing, sweating, reduced consciousness, and sudden change in blood pressure and heart rate.)
    • Suicidal thoughts and suicide attempts
    • Painful and/or sustained erection
    • Tardive dyskinesia (As with all antipsychotic medication, patients using aripiprazole may develop the permanent neurological disorder tardive dyskinesia. Stroke (While taking aripiprazole some elderly patients with dementia have suffered from stroke or 'mini' stroke.)
    • Allergic reaction (such as swelling in the mouth or throat, itching, rash), speech disorder, nervousness, agitation, fainting, reports of abnormal liver test values, inflammation of the pancreas, muscle pain, weakness, stiffness, or cramps.

    US Food and Drug Administration (FDA) Approval Dates Aripiprazole

    • Schizophrenia on November 15, 2002 and the European Medicines Agency on 4 June 2004;
    • Acute Manic and mixed episodes Bipolar Disorder on October 1, 2004; Major Depressive Disorder on November 20, 2007;
    • Irritability in children with Autism on 20 November 2009.

    Funny Research Aripiprazole

    Two large, double-blind, placebo-controlled studies found no difference between aripiprazole and placebo.[***] One study reported depression as a side effect of the drug.[*****] Image Credit: http://www.indiamart.com/apollolife/anti-psychotic-product.html Source: http://en.wikipedia.org/wiki/Aripiprazole
    *** ^ Thase ME, Jonas A, Khan A, Bowden CL, Wu X, McQuade RD, Carson WH, Marcus RN, Owen R (February 2008). "Aripiprazole monotherapy in nonpsychotic bipolar I depression: results of 2 randomized, placebo-controlled studies". J Clin Psychopharmacol 28 (1): 13–20. doi:10.1097/jcp.0b013e3181618eb4. PMID 18204335.
    ***** ^ Muzina DJ, Momah C, Eudicone JM, Pikalov A, McQuade RD, Marcus RN, Sanchez R, Carlson BX (May 2008). "Aripiprazole monotherapy in patients with rapid-cycling bipolar I disorder: an analysis from a long-term, double-blind, placebo-controlled study". Int. J. Clin. Pract. 62 (5): 679–87. doi:10.1111/j.1742-1241.2008.01735.x. PMC 2324208. PMID 18373615.
    Retrieved on December 11, 2012 Reviewed by
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